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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8108 | Blu-782 | ALK2-IN-1 | ALK |
Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM) | |||
T10287 | ALK2-IN-2 | ALK , TGF-beta/Smad | |
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3. | |||
T2098 | A 77-01 | A77-01 | ALK , TGF-beta/Smad |
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. | |||
T77019 | Garetosmab | REGN 2477 | TGF-beta/Smad |
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cancer activity and can be used to study ossifying fibrous dyspl... | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T1800 | GW788388 | GW 788388 | ALK , TGF-beta/Smad |
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities. | |||
T24562 | NUCC-555 | ||
NUCC-555 is a first-in-class antagonist of activin. It opens a completely new approach to inhibiting the activity of TGF-beta receptor superfamily members. | |||
T13139 | TP-008 | TGFβRI-IN-2 | Others |
TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively). | |||
T81410 | Prafnosbart | DS-6016A | |
Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized in research on bone metabolism disorders [1]. | |||
T62117 | ALK5-IN-34 | ||
ALK5-IN-34 is a selective, orally active inhibitor of activin receptor-like kinase (ALK), which inhibits the activity of activin receptor-like kinase (IC50 ≤ 10 nM) and also inhibits tumour growth. | |||
T62614 | ALK5-IN-29 | ||
ALK5-IN-29 is a selective inhibitor of activin receptor-like kinase (ALK).ALK5-IN-29 inhibits activin receptor-like kinase activity (IC50 ≤ 10 nM).AALK5-IN-29 inhibits tumour growth and can be used in the study of prolif... | |||
T76995 | Sotatercept | ||
Sotatercept (ACE-011), a soluble activin receptor type IIA (ACVR2A) IgG Fc fusion protein, aims to rebalance growth-promoting and inhibiting signaling pathways by targeting activin and growth differentiation factors. Thi... | |||
T76860 | Bimagrumab | ||
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody targeting the activin type II receptor (ActRII), exhibiting binding affinities (K D) of 1.7 pM for ActRIIB and 434 pM for ActRIIA, respectively. ... | |||
T35541 | Lipoxygenin | ||
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-de... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01471 | Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant | Human/Mouse/Rat | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purifi... | |||
TMPY-00654 | ACVR2B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ACVR2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is Q13705-1. | |||
TMPY-01281 | ACVR2B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1. | |||
TMPY-01447 | ACVR2A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ACVR2A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A2AI38. | |||
TMPY-01744 | ACVR2A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1. | |||
TMPY-04774 | ALK-2/ACVR1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
ALK-2/ACVR1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.8kDa and the accession number is Q04771. | |||
TMPY-01168 | ALK-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310. | |||
TMPY-03157 | ALK-2/ACVR1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
ALK-2/ACVR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.5 kDa and the accession number is P80201. | |||
TMPY-03300 | ALK-4/ACVR1B Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
ALK-4/ACVR1B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is P80202. | |||
TMPY-03706 | ALK-2/ACVR1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
ALK-2/ACVR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.6 kDa and the accession number is A0A8C0MPL7. | |||
TMPY-03100 | ALK-4/ACVR1B Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
ALK-4/ACVR1B Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is I2CYX8. | |||
TMPY-04044 | ACVR2B Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells |
ACVR2B Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.1 kDa and the accession number is G7MJ10. | |||
TMPY-03925 | ACVR2B Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
ACVR2B Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.3 kDa and the accession number is G7MJ10. | |||
TMPY-03827 | ACVR2B Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
ACVR2B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa. | |||
TMPY-01846 | Activin A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two ... | |||
TMPY-03187 | ALK-7 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
ALK-7 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is F7GDQ6. | |||
TMPY-03707 | ALK-2/ACVR1 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
ALK-2/ACVR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is A0A8C0MPL7. | |||
TMPY-03247 | ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is F7A9J8. | |||
TMPY-01051 | ACVR2B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ACVR2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q13705-1. | |||
TMPY-03315 | ALK-1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
ALK-1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.8 kDa. | |||
TMPY-03678 | ALK-1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
ALK-1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 12.2 kDa and the accession number is E2R174. | |||
TMPY-01022 | ACVR2B Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
ACVR2B Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41 kDa and the accession number is P27040-1. | |||
TMPY-01602 | ACVR2A Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
ACVR2A Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A2AI38. | |||
TMPY-00757 | ALK-1 Protein, Rat, Recombinant (His & hFc) | Rat | HEK293 Cells |
ALK-1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.7 kDa and the accession number is A6KCN1. | |||
TMPY-00310 | ALK-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
ALK-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is A0A2K5WXU2. | |||
TMPY-00486 | ALK-7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ALK-7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is Q8NER5-1. | |||
TMPY-00659 | ACVR2A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is P27037-1. | |||
TMPJ-00304 | ALK-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi... | |||
TMPY-00662 | ALK-1 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
ALK-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39 kDa and the accession number is Q61288. | |||
TMPY-05483 | ALK-4/ACVR1B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1. | |||
TMPY-00444 | ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is Q3TZF1. | |||
TMPY-01293 | ALK-4/ACVR1B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ALK-4/ACVR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P36896-1. | |||
TMPJ-01158 | ALK-2/ACVR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formati... | |||
TMPY-00658 | ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is D3DPA4. | |||
TMPY-01096 | ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 40 kDa and the accession number is P37172. | |||
TMPY-00650 | ALK-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310. | |||
TMPJ-01178 | TGFBR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho... | |||
TMPY-01190 | INHBB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two ... | |||
TMPY-00975 | FSTL3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall str... | |||
TMPJ-00314 | ACVR2B Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors... | |||
TMPJ-00315 | ACVR2A Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation fact... | |||
TMPH-02748 | KCP Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways. KCP Protein, Mouse, Recombinant (His & Myc) is expressed in E.... | |||
TMPK-00751 | FSTL3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both huma... | |||
TMPY-03419 | SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) | Human,Mouse,Rat | Baculovirus Insect Cells |
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is... | |||
TMPK-00153 | BAMBI Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) is a transmembrane protein that affects the growth, development and muscle regeneration of the body by regulating the TGF-β, BMP and Wnt signaling pat... | |||
TMPH-01699 | SMAD2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in t... | |||
TMPJ-01015 | INHBC Protein, Human, Recombinant (C-His) | Human | HEK293 Cells |
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disul... | |||
TMPY-03291 | SMAD2 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells |
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD... | |||
TMPJ-00966 | GDF-5 Protein, Human, Recombinant | Human | E. coli |
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor... | |||
TMPY-01814 | GASP-1/WFIKKN2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2, also known as Growth and differentiation factor-associated serum protein 1, WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-relat... | |||
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